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Once chronic hyperglycemia is corrected, GIP-mediated insulin secretion is restored [78], allowing tirzepatide to enhance insulin secretion through both the GIP and GLP-1 receptors (Fig
PMC Katagiri K, Koyama S, Takeda K, et al
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doi: 10.23937/2378-3656/1410150 Summary Keywords euglycemic diabetic ketoacidosis (euDKA), SGLT-2 inhibitor, GLP-1 receptor agonist, type 2 diabetes mellitus, adverse drug reaction Citation Gandecka-Pempera A, Naskrt D, Adamska A and Zozuliska-Zikiewicz D (2025) Severe euglycemic ketoacidosis following combined therapy with GLP-1 receptor agonist and SGLT-2 inhibitor, refractory to standard treatment: a case report