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Non-alcoholic fatty liver disease (NAFLD) and its advanced form, non-alcoholic steatohepatitis (NASH), are driven by metabolic inflammation, with Kupffer cells (liver macrophages) and hepatocytes producing inflammatory mediators in response to lipotoxicity [275, 276]

The following section will describe the relationships and molecular mechanisms of GPxs in disease development

Symptoms of nutritional deficiency are pale skin, fatigue, weakness, trouble breathing, feeling faint, and poor concentration

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Copper is a required cofactor for lysyl oxidase, the enzyme that cross-links collagen and elastin which offers a route by which a copper carrier could affect matrix quality