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The basis is evidence absence, not commercial threat [9]

Microneedle first, then apply GHK-Cu immediately after

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For peptides that do not dissolve cleanly in bacteriostatic water alone typically those with hydrophobic sequences or basic amino acid-rich compositions that require protonation for solubilisation the recommended approach is to first perform initial reconstitution in a small volume of 0.1% acetic acid water (also available from Peptides Lab UK) to produce a clear stock solution, before diluting further with bacteriostatic water or the relevant physiological buffer