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Yet, whether Rho/ROCK directly mediates TGR5 effects in vivo remains to be confirmed by additional experiments, such as in vivo gene knockout models and Western blot analysis of hypothalamic tissue [68]

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Persistent nausea or vomiting that is not improving after the first few weeks, or that is significantly affecting their ability to eat or function Mood changes that are lasting beyond the initial adjustment period, or that are notably affecting their daily life or your relationship Significant fatigue that is not improving as treatment progresses Signs of nutritional difficulty, such as extreme weakness, hair loss, or other symptoms that suggest they are not meeting nutritional needs Any change in how the medication is making them feel that they seem reluctant to raise because they do not want to seem like they are complaining or asking for the treatment to stop Your role here is not to diagnose or to manage their treatment

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