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Trimethylamine N-oxide (TMAO) is produced from the metabolism of dietary choline and L-carnitine by intestinal microbiota, and many studies have shown that this important product inhibits cholesterol metabolism, induces platelet aggregation and thrombosis, and promotes atherosclerosis

It works at a cellular level, helping the body use fat as a steady, efficient energy source, which is particularly useful for horses on restricted diets, those struggling to maintain topline, or those in work or rehabilitation

ED is widely considered an early hallmark of CVD and is particularly prevalent in individuals with insulin resistance, hyperglycemia, and T2DM (6)

While extensive studies have focused on leptins actions in the hypothalamus in the regulation of feeding and energy metabolism [10, 11], LepRb is also highly expressed in extra-hypothalamic brain regions including the hippocampus, which is implicated in mood regulation [4, 12,13,14]

Now, online businesses are trying to cash in on the craze by selling skin patches marketed for weight loss that include GLP-1 in the product name, but are not actually GLP-1 agonist drugs