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In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)
Bacteriostatic water for reconstitution adds $12$18 per 30mL vial, insulin syringes cost $8$15 per box of 100, and alcohol prep pads run $6$10 per 100-count box
Obesity is a growing epidemic that affects millions of people worldwide, leading to serious health complications such as heart disease, diabetes, and certain cancers
These effects have been confirmed in animal experiments, but not in humans, and the specific mechanism remains unknown
PMID: 50 ZhangCWeiSDaiSLiXWangHZhangHet al
