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Since its identification in the 1990s by the research group of Sikiric et al., it has become one of the most extensively studied peptides in tissue repair research, with published data spanning tendon healing, angiogenesis, nitric oxide regulation, and gastrointestinal cytoprotection

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In MAFLD, hepatic lipid accumulation induces excessive ROS production, which in turn promotes lipid peroxidation, accelerates lipid accumulation, and induces cellular damage