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Until recently, all actives were tested on the mushroom enzyme, but the human enzyme is of course much more complex
Cleven AH, Sannaa GA, Briaire-de Bruijn I, Ingram DR, van de Rijn M, Rubin BP, et al
NPI-001 is lipophilic and easily permeates cell membranes
Furthermore, ammonia has been observed to activate SREBP-1, thus establishing a feed-forward loop that promotes glutamine metabolism and lipid synthesis, as well as tumor cell proliferation [24]