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A recent phase 2 trial testing doses of up to 16 mg/week suggests that, while higher doses yield further improvements in blood glucose and body weight, there is no clinical justification for exceeding the approved dose of 2 mg/week due to increased frequency of AEs
The weight loss advantage of retatrutide over tirzepatide appears to be approximately 6 percentage points at the highest doses, a clinically meaningful difference
International Journal of Molecular Sciences, 25 (5), 2952
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