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Probiotics (live beneficial microorganisms), prebiotics (selectively fermentable substrates), and postbiotics (microbial-derived metabolites or functional components) represent complementary approaches aimed at improving gut microbial composition and function, thereby potentially reinforcing incretin signaling and metabolic outcomes (108)
Merck discontinued -amino acid-containing molecules due to a lack of selectivity and focused instead on selective amino acid piperazine derivatives, which led to the development of sitagliptin, a compound containing piperazine and triazolopiperazine
Kohan DE, Fioretto P, Tang W, List JF
10.2337/dc13-2855 46 LingvayI.Prez ManghiF.Garca-HernndezP.NorwoodP.LehmannL.Tarp-JohansenM
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