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10 A plot of log BBB permeability (cm/sec) versus log octanol-water partition coefficient shows that increased lipophilicity directly correlates with increased membrane permeability in that the more lipid soluble a molecule is, the more readily it moves from the aqueous environment of blood across the lipid environment of the endothelial cell (EC) membrane and enters the brain
All tissues were frozen in Tissue-Tek O.C.T (Sakura Finetek, 4583), cut in 1214 m sections and placed on microscopic slides (Thermo Fisher Scientific, 10149870)
