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J Hepatol 73:S4-S5 Erstad DJ, Farrar CT, Ghoshal S et al (2018) Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP-305, a novel farnesoid X receptor agonist
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Plant polyphenols, such as resveratrol found in grapes and red wine, can activate key regulatory pathways involving sirtuins and the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), which promote the expression of genes involved in mitochondrial function 15,16,17
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This decline has been associated in research with disrupted circadian signaling and diminished antioxidant capacity, as melatonin is both a direct free radical scavenger and a regulator of antioxidant enzyme expression
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