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It was first isolated from human plasma albumin by Pickart and Thaler in 1973 and is found endogenously in plasma, saliva, and urine
F., Fischman, A
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(2006) characterized TREK-1 knockout mice and observed resistance to behavioral despair paradigms, elevated serotonin levels, and increased hippocampal neurogenesis, establishing the rationale for TREK-1 blockade [3]
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