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If SAM pools remain elevated due to reduced NNMT activity, downstream methylation pathways could theoretically be affected

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Like other GLP-1s (glucagon-like peptide-1 receptor agonists), semaglutide works best when combined with lifestyle interventions including a reduced-calorie diet and exercise

Managing Side Effects Like any medication, semaglutide can have side effects, particularly as you increase your dosage

This side effect is generally transient but should be monitored if: You experience palpitations Theres a noticeable, sustained increase over time Its advisable to have regular cardiac assessments while on GLP-1 medication, especially if you have underlying heart conditions