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The side effects, which are likely to subside over time, may include: Nausea Diarrhea Constipation Vomiting Heartburn Headaches GERD (Gastroesophageal reflux disease) Starting at low doses may help circumvent these, says Kushner, who also notes that these side effects can usually be alleviated if people eat low-fat foods, smaller portion sizes, and a balanced meal plan