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A 2026 systematic review and meta-analysis of controlled human trials found that allulose (and its cousin tagatose) meaningfully reduced the postprandial glucose response when used in place of added sugars, an effect that may be especially useful in the window right after a carbohydrate-rich meal

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In addition, methylenetetrahydrofolate reductase requires riboflavin to ensure normal folate cycle influencing the methylation cycle and consequently homocysteine levels which have its own negative neurovascular consequences if accumulated