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Patients should inform their physician if they have: Personal history of any cancer, including colorectal cancer or polyps Family history of colorectal cancer, especially in first-degree relatives Inflammatory bowel disease (Crohn's disease or ulcerative colitis) Genetic syndromes associated with increased cancer risk (Lynch syndrome, familial adenomatous polyposis) Previous radiation therapy to the abdomen or pelvis These factors affect baseline colorectal cancer risk independent of medication use

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Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Reta initiation Weeks 1-4 Retatrutide 2 mg/week Cagrilintide Not started Notes Confirm retatrutide GI tolerance first