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Because your body uses and excretes B12 rather than storing unlimited amounts, consistent timing helps keep your energy and focus steady instead of peaking and crashing. Many people find that taking B12 late in the day can make them feel more alert right when they are trying to wind down, which may interfere with sleep
Because so little is absorbed, they are taken daily
Appetite reduction is noticeable within days
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My resting heart rate went up 5 bpm Reported as a mild stimulant-like effect in the first 1 to 2 weeks
