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Specifically, this research aims to clarify the potential mechanisms underlying bromelains therapeutic actions by assessing its ability to reduce oxidative biomarkers (TOS, TAS, OSI), modulate inflammatory cytokine levels, and evaluate histopathological changes, including muscle degeneration, atrophy, central nuclear internalization, and leukocyte infiltration 17
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It was found that both AOD9604 and hGH resulted in fat loss in association with increased fat oxidation as well as increased levels of glycerol (relating to lipolysis), However, an added benefit of AOD9604 was that it did not lead to hyperglycemia in the mice or reduced insulin sensitivity
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