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Interestingly, animal model studies employing dietary choline or TMAO, germ-free mice and microbial transplantation confirmed a role for gut microbiota-dependent TMAO production in modulating platelet hyperresponsiveness and thrombotic potential (78)

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There was a significant nonlinear relationship between the duration of intervention and changes in FBG, HbA1c, and HOMA-IR

Journal of Endocrinology, 1996