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Which approach is right, or whether each suits a different patient group, is an open question the field will not resolve quickly

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4 Moreover, females exhibit a biologically distinct metabolic context from males, shaped by sex-specific physiological programs, including pregnancy and lactation, which involve profound shifts in lipid metabolism and carnitine demand, 8 which remain largely unexplored

Neurovascular and repair endpoints include BBB leakage, tight-junction and pericyte coverage, perfusion, myeloid metabolic phenotype, and oligodendrocyte/white-matter integrity [14, 17, 18, 23, 25, 27,28,29]