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Primary pain in ALS includes neuropathic pain and pain due to spasticity or cramps, whereas secondary pain is mainly nociceptive and may appear as muscle weakness and atrophy progress [83]
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Further escalation to 2-2.4 mg daily follows after another 2-4 weeks if needed
The uricosuric agents targeting the URAT1 transporter, such as lesinurad and dotinurad, along with the formulation of oral combination therapies comprising xanthine oxidase inhibitors and uricosuric agents, is poised to improve the attainment of the target serum uric acid level of less than 6 mg/dL
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