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Some researchers and clinicians advocate for the higher end of this range, up to 2.4 grams per kilogram, when fasting is combined with caloric restriction and GLP-1 therapy
The potential mechanisms underlying the increased risk of gastric aspiration are not fully understood, and nowadays it is explained mainly by delayed gastric emptying and inhibition of gastrointestinal motor function that GLP-1-RAs exert through both central motor nuclei and vagal afferents [13, 14]
Fold changes are finally given as the average fold change of replicates with the error bars which represent s.d
Even if the vial looks clear afterward, activity can be reduced compared with gentle handling
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