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found that circ_0001273, as a cancer-promoting factor that upregulates SLC1A5 expression by binding to miR-622, which increases Gln uptake by tumor cells, consequently enhancing tumor growth and inhibiting cell apoptosis (57)

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The dual mechanism was confirmed at the cellular level, and the fragment showed no cross-reactivity with the growth hormone receptor (Ng & Borstein, 2003)

Older skin has lower baseline GHK levels and theoretically more room for response