RNA, protein, and enzymatic evidence In the serum of 30 patients with bipolar depression, oxidant nitric oxide levels were increased while antioxidant SOD levels were decreased compared to healthy controls, suggesting that the ability to cope with oxidative stress is impaired in bipolar depression [83]
The rationale for titrating upward over time, rather than starting at the target dose, mirrors the approach taken with other metabolic peptides: the goal is to identify the minimum effective dose for each individual while monitoring for tolerability
doi: 10.1016/j.jff.2018.09.008 26
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