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Metformin remains a common foundation for type 2 diabetes because it is familiar, oral, and widely available
The drug functions similar to human glucagon-like peptide-1 (GLP-1) by increasing insulin secretion, which leads to improved sugar metabolism
The FDA has sent several warning letters to GLP-1 compounders using salts, as well as companies selling drugs with non-FDA-approved peptide therapies retatrutide and cagrilintide for weight loss, over the last few years
Taking them both together may further raise your risk of gastrointestinal (GI) distress
Peripherally administered PYY(3-36) crosses the blood-brain barrier to act on Y2R-expressing NPY/AgRP neurons in the hypothalamic arcuate nucleus, inhibiting their activity and enhancing satiety signals (60, 87, 88)
