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Supplementary Table 1), and in people of European ancestry 11 (BMI % = 12.1% in Europeans versus 10.6% in non-Europeans
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Self-injecting is not for everyone, and that is completely okay
At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems
These are people whove spent years being told their bodies were a moral failure, tried and failed a dozen times on advice that wasnt going to work, and have now opted in to a process that demands a major rebuild of their daily life on top of the side effects of the medication itself
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