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Pemvidutide (ALT-801) is another unimolecular once weekly GLP-1/glucagon agonist undergoing a phase 2 trial as obesity treatment, following a phase 1 trial demonstrating up to 10.3% WL at 12 weeks [73]
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Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes
Under normal physiological conditions, small amounts of 5-oxoproline are derived from gamma-glutamyl-cysteine by the action of gamma-glutamyl cyclotransferase (63)
doi: 10.1053/j.gastro.2023.11.019
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