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The ethanol extract at 200 and 400 mg/kg could strongly decrease IL-1, cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), and myeloperoxidase (MPO) serum levels compared to the control group not provided with the extract ( in vivo inhibition of Th2-cell-driven response to the allergen

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Hong Hy, Lee HY, Kwak W, Yoo J, Na MH, So IS, et al

This applies to both unopened and opened vials

BPC-157 is not FDA-approved for therapeutic use and should be considered investigational