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Evidence synthesis: We integrate RCT evidence on weight and metabolic outcomes with exploratory findings on reproductive outcomes, highlighting key effect modifiers (baseline obesity/IR phenotype, concomitant metformin, and follow-up window)

Control, Variability, and What Can Change Decision-making inside the Measured program is divided across the platform, licensed clinicians, and pharmacies, with authority shifting by stage

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The first step is determining whether the current plan is being followed, tolerated, and aimed at the correct problem