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Cauter, E
The angiogenic response is augmented and temporally shifted toward earlier vessel formation, providing oxygen and nutrients to regenerating tissue during critical early healing phases
This effect was associated with the upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) expression at both the mRNA and protein levels
However, since the tubular reabsorption occurs via an active transporter, once the transporter is saturated by the high plasma L-carnitine concentrations achieved by intravenous administration, the circulating L-carnitine is rapidly excreted
