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Larger and more diverse patient cohorts are needed, lower dosages of semaglutide have to be tested, and follow-ups need to be conducted beyond 26 weeks.
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This pause allows tirzepatide's effects to substantially diminish before introducing semaglutide's distinct biological signaling, reducing the potential for compounded gastrointestinal symptoms or medication interactions
While overall prescribing of semaglutide increased throughout second quarter of 2024, the rate of first-time prescribing of semaglutide slowed from 0.9% of prescriptions in May 2024 to 0.7% in June 2024
Alkhazaali-Ali et al., 2024)
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