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Changes in NNMT activity shouldnt be interpreted as producing predictable changes in NAD+ levels across all biological systems
[5] That finding should not be expanded into a universal claim that AOD9604 directly activates CPT1, increases mitochondrial number, induces oxidative gene expression, or increases fatty-acid oxidation in every tissue or model
(1) Both these findings on chronic and acute action of AOD 9604 suggested that while enhanced beta(3)-AR expression may have played a role in the chronic action of the compound, beta(3)-AR might not be the sole arbiter in this reaction
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