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dose adjustments of concomitant medications may be necessary Renal function : Dehydration from gastrointestinal side effects may precipitate acute kidney injury, particularly in patients with pre-existing renal impairment
Second, the gap between tirzepatide and retatrutide (approximately 6 percentage points) is smaller than the gap between semaglutide and tirzepatide (approximately 7-8 percentage points), which means the incremental benefit of adding glucagon agonism is real but not proportionally larger than the benefit of adding GIP
K.WakoK.MaruoS.KakutaS.TaguchiT.IkunoM.et al (2020)
The rate varies significantly between individuals, influenced by starting weight, diet, activity level, and metabolic factors
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