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GLP-1 RAs are considered a safe and effective option for fasting patients because they use a glucose-dependent mechanism
These unknowns do not invalidate the existing safety data
The discovery of semaglutide can be traced back to Novo Nordisk's extensive research on GLP-1 analogs aimed at improving diabetes treatments
20 This observation emphasizes their potential to promote systemic metabolic health beyond glucose homeostasis and makes GLP-1RAs a more suitable treatment option for T2D patients with a higher risk of cardiovascular disease compared to metformin
Obesity associates with reduced testosterone due to increased aromatase activity in adipose tissue converting testosterone to estrogen
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