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1 Introduction Cancer, an increasingly prevalent disease internationally, has become one of the principal causes of morbidity and death globally, with serious economic costs to society

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Nonetheless, whether the specific mechanism of this is related to the transdifferentiation of VSMCs to a bone-like phenotype, loss in SMC lineage markers, enhanced pro-calcific microRNAs, increased intracellular calcium level, apoptosis, or aberrant DNA damage response (DDR) requires further investigation

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