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So while oral may seem cheaper on the surface, its actually a high-risk choice with unknown quality

Patients who maintain their results beyond 12 weeks are those who adjusted caloric intake downward as weight decreased, incorporated refeed days to manage leptin suppression, and understood that the injections support the process but don't override thermodynamics

People often feel sick, have diarrhea or constipation, and get stomach aches [12]

doi: 10.1007/s00405-016-4058-6 44 DateYEbisawaMFukudaSShimaHObataYTakahashiDet al

That means that a big open question is whether the side effect profiles may differ in subgroups of people that scientists have not directly studied, which include a large swath of people now taking these drugs to lose only about 10 to 15 pounds