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Studies on athletes show whole-body cryotherapy reduces circulating levels of the pro-inflammatory cytokine IL-1 beta while increasing the anti-inflammatory cytokine IL-10 and the cytokine inhibitor IL-1 receptor antagonist (IL-1ra)

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For instance, individuals with postural orthostatic tachycardia syndrome following COVID-19 display IgG auto-Abs against cytokines [373], G-protein coupled receptors such as angiotensin receptor and nociception-like opioid receptor [374], and nuclear antigens [375]