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Enzo Spisni, [email protected] These authors have contributed equally to this work $ These authors have contributed equally to this work and share last authorship ORCID: Fabio Vivarelli, orcid.org/0000-0002-8734-0985 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Comput Biol Med 168:107785 Rakha SI, Elmetwally MA, El-Sheikh Ali H, Balboula A, Mahmoud AM, Zaabel SM (2022) Importance of antioxidant supplementation during in vitro maturation of mammalian oocytes

Reduced production of TNF-, IL-6, IL-1, and IL-8, as well as downregulation of iNOS, reduces systemic low-grade inflammation and limits inflammatory spillover to the CNS [153, 154]

PKM2 PKM2 is a key enzyme in the last step of glycolysis, converting phosphoenolpyruvate to pyruvate and supplying ATP [92]

10.1038/mt.2013.183 60 JiangZ.ZhaoP.ZhouZ.LiuJ.QinL.WangH