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The method of item 26, wherein the polar hydrophilic ligand prior to chemical attachment to the at least one stimulant is selected from the group consisting of carnitine, benzoic acid, tartaric acid, biotin, citric acid, pantothenic acid and salts, choline, cystine dimer, lactic acid, niacin, riboflavin, thiamine, Vitamin A, Vitamin B12, Vitamin D2, Vitamin D3, ascorbic acid, ethylene diamine tetraacetic acid (EDTA), t-butylated hydroxyanisole (BHA), propionic acid, sorbic acid, erythorbic acid, methyl paraben, propyl gallate, propyl paraben, thiodipropionic acid, propylene glycol, pyridoxine, adipic acid, succinic acid, malic acid, acetoin, N-butyric acid, vanillin, geraniol, methyl anthranilate, benzoin, benzyl alcohol, derivatives thereof, and combinations thereof

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2.2 Animals and treatment The animal experiments were approved by the Ethical Review Committee of the Institute of Zoology, Capital Medical University, China (TRLAWEC2025-08)