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499 A and phosphorylated Tau (p-Tau) neurofibrillary lesions lead to the pathology of neurons that display oxidative damage, impaired Ca2+ processing, reduced DNA repair, dysfunction of lysosomal and mitophagy, all of which have a positive correlation with the age-related NAD + decline
Other drugs can also be used, such as Amitriptyline, Ketamine, Topiramate, Tapentidol and Duloxetine
Allison T
(PubMed) Steiner M, Li W
(2010) Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism
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