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Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk
Brigelius-Floh R, Maiorino M (2013) Glutathione peroxidases
Mechanism of Action of GLP-1RAs in Type 2 Diabetes These effects have positioned GLP-1RAs as a cornerstone in the management of type 2 diabetes, particularly in individuals with obesity
General stacking rules: never combine two peptides that act on the same receptor at the same time
According to the National Institute of Diabetes and Digestive and Kidney Diseases, adults who are overweight or obese should lose 5% to 10% of their body weight within 6 months for weight loss success and better outcomes (12)
