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Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice

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Through binding to the TRAIL receptors TRAILR1/Death Receptor 4 (DR4) and TRAILR2/DR5, TRAIL induces apoptosis through Fas-associated death domain (FADD)-dependent recruitment and activation of caspase-8, termed the Death-inducing Signalling Complex (DISC)