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Meanwhile, HEFDS composed of magnetic nanoparticles modified with cationic polyethyleneimine (PEI), selenocysteine (Sec), and sodium hyaluronate (HA), can form HEFDS-NK cells through co-culture with NK cells and can reach tumor sites with the assistance of HA and magnetic field targeting, where Sec can enhance the immune activity of NK cells, producing Granzyme B, Perforin, and IFN-, ultimately achieving effective tumor treatment (93)
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Overall, this trial was designed to precisely determine the dose-response relationship, efficacy, and safety of Cagrilintide compared with placebo and liraglutide, while employing advanced statistical methods to ensure reliable interpretation of treatment effects under both ideal and real-world adherence conditions
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