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Endothelial dysfunction during acute methionine load in hyperhomocysteinaemic patients
Dosing frequency must account for the pharmacokinetic clearance (how often you need to re-activate receptors) rather than the pharmacodynamic persistence (how long you see visible effects)
Methods Animal housing Male and female wild-type C57BL/6J mice were purchased (The Jackson Laboratory, Bar Harbor, USA) and bred in-house
In some experimental settings, Tesamorelin (a GHRH analog) and Ipamorelin (a ghrelin receptor agonist) may be studied together to examine combined pathway activation of the GH axis
IF/TA, Interstitial fibrosis/tubular atrophy
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