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However, this does not mean you are immune to metabolic slowdown

Compared with nonusers, adults taking GLP-1s had a: 17 percent lower risk of venous thromboembolism, or blood clots in the veins 31 percent lower risk of pulmonary embolism, a potentially life-threatening clot that travels to the lungs 21 percent lower risk of going to the emergency department 44 percent lower risk of all-cause mortality (death from any cause) Researchers also observed lower stroke rates among GLP-1 users, although this difference didnt reach statistical significance

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or a similar program may be a required step

Patients with certain FTO variants, for example, show accelerated hunger return after GLP-1 discontinuation and benefit from longer taper schedules and more intensive dietary intervention