This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH
Its molecular structure was optimized through genetic engineering technology: an additional 13 amino acids were added to the N-terminus of natural IGF-1 (70 amino acids, molecular weight 7.4 kDa) to form a long-chain structure of 83 amino acids (molecular weight 9.11 kDa), and the third glutamic acid (Glu) was replaced with arginine (Arg), hence the name "R3"
Last but not least, the fizziness gives a refreshing boost to the consumer experience, making it more enjoyable and appealing
The Endocrine Society's 2020 position statement on compounded hormones and peptides emphasizes that "compounded preparations should be used only when an FDA-approved product is not available or is not suitable for a particular patient" [12]
It is important to be precise about the evidence
