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By evading this sequestration, IGF-DES is able to engage the IGF-1 receptor (IGF-1R) more directly, making it a uniquely valuable research tool for studying IGFBP-independent IGF-1 receptor signalling

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Meanwhile, HUMAnN [125] (HMP Unified Metabolic Analysis Network) is used to reconstruct host-microbiome metabolic interactions at high resolution, linking microbial pathways with host metabolic responses (Table 2)

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