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A negative trial result may indicate lack of drug access to the brain, rather than failure of the concept itself, Paul Edison, a professor of neuroscience at Imperial College London, explained

Fluoxetine also decreased the activity of 17-beta-hydroxysteroid dehydrogenase type 6 (17-HSD6), a steroidogenesis-related enzyme, and lowered serum testosterone levels by affecting the steroidogenic capacity of Leydig cells

Since PSEN1 is an active center of -secretase, the activity of -secretase may also be increased by oxidative stress 21

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