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60 In a previous study, we demonstrated the increased sensitivity of autism lymphoblastoid cells to acute NO-induced mitochondrial membrane depolarization, and others have reported elevated plasma and red blood cells levels of nitrites in children with autism

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Importantly, these findings provide a mechanistic explanation for the limited diagnostic value of circulating zinc measurements and the variable clinical efficacy of nonspecific zinc supplementation, which fail to capture or correct compartment-resolved zinc dysregulation

Unraveling the role of inflammation in the pathogenesis of diabetic kidney disease